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Contract Research Organization

Alfa CDMO's CRO offers custom services for research, optimization, and development phases of your project.

ANTIBODY ENGINEERING

Protein Expression

  • Gene synthesis, vector construction.
  • Transient expression 6-8 weeks, 0-500 mg proteins.
  • Antibody / Bispecific Antibody / Fusion protein / Antigen.

Antibody Humanization

  • Start with sequence of the mouse-origin monoclonal antibody, design, construct, screening.
  • Short time (2 months) and higher binding affinity.

Antibody Fc Engineering

  • ADCC increase / weaken
  • CDC increase / weaken
  • ADCP increase / weaken
  • FcRn binding increase / weaken
  • Antibody design for ADC

CHEMICAL SYNTHESIS

Design and Synthesis of Linker-Payloads

  • A library of ready-for-use Linker-Payloads for rapid ADC screening.
  • Design and synthesis of customized Linker-Payloads.
  • Synthesis process development of Linker-Payloads and related precursors.
  • Milligram to gram scale supply of Linker-Payloads and precursors.

ANTIBODY DRUG CONJUGATION SCREENING

ADC Conjugation Service

We are very familiar with the linkage strategy:
  • Lysine-based conjugation
  • Cysteine-based conjugation (Single-thiol conjugation /Double-thiol covalent conjugation)
  • Site-specific conjugation
We have rich experience for different antibody & different linker-payloads:
  • For different types of antibody (IgG1/ IgG2 / IgG4 / Bi-specific antibody)
  • For different kinds of Linker- Payloads

ADC Assay and Mechanism Study

ADC analysis (For early stage)
  • DAR / Free drug ratio / Concentration / Purity etc.
ADC Mechanism Study (For early stage)
  • Tumor inhibition potency evaluation assay
  • Binding affinity activity assay
  • Antigen expression level detection
  • Endocytosis activity assay
  • Stability in serum assay
  • Animal experiment (Tumor Models /MTD/PK/PD— mouse/rat)
Inquiry

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Online Inquiry